PE-Cy7 Rat Anti-Mouse/Human CD45R/B220 Antibody (S-R519)

產(chǎn)品型號：S0B5262

更新時間：2025-06-29

廠商性質(zhì)：生產(chǎn)廠家

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產(chǎn)品介紹

CD45R/B220 is an isoform of the CD45 protein, a member of the protein tyrosine phosphatase （PTP） family, and serves as a critical regulator of T- and B-cell antigen receptor signaling. It is predominantly expressed on the surface of B cells, from early pro-B cells to mature and activated B cells, making it a commonly used pan-B cell marker in mice. Additionally, CD45R/B220 is also found on certain subsets of activated T cells, lymphokine-activated killer cells （LAK）, NK cell progenitors, and T cells in mutant mice. This molecule plays a crucial role in lymphocyte development and antigen signaling, and its expression is regulated during different stages of B cell maturation.

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