E-Cadherin Recombinant Rabbit mAb (Cy5 Conjugate) (S-438-5)

產(chǎn)品型號(hào)：S0B0148

更新時(shí)間：2025-06-30

廠商性質(zhì)：生產(chǎn)廠家

訪問量：28

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ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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IHC腫瘤標(biāo)志物 | 常見前列腺癌診斷

HA標(biāo)簽重組兔單抗具有增強(qiáng)蛋白定位的能力

產(chǎn)品介紹

E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF （Lymphoid enhancer factor）/TCF （T cell factor） which serves the function of transcribing genes of the proliferative Wnt signaling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition （EMT）, E-cadherin functional loss has frequently been associated with poor prognosis and survival in patients of various cancers. The dysregulation of E-cadherin expression that leads to carcinogenesis happens mostly at the epigenetic level but there are cases of genetic alterations as well. E-cadherin expression has been linked to the cellular functions of invasiveness reduction, growth inhibition, apoptosis, cell cycle arrest and differentiation.

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