IL-29/IL-28 Recombinant Rabbit mAb (SDT-1838-9)

產(chǎn)品型號(hào)：S0B3403

更新時(shí)間：2025-06-29

廠商性質(zhì)：生產(chǎn)廠家

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抗體/抗原

ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對(duì)抗體病理/IHC抗體

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產(chǎn)品介紹

IL-28A, IL-28B, and IL-29, also named interferon-lambda 2 （IFN-lambda 2）, IFN-lambda 3, and IFN-lambda 1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family （11-13% a.a. sequence identity） and the type IIFN family （15-19 % a.a. sequence identity）. The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and upregulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor lambda （IL-10 R beta） and a novel IL-28 receptor alpha （IL-28 R alpha, also known as IFN-lambda R1）. Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation.

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